Molecular Formula | C2H8N2O4S2 |
Molar Mass | 188.23 |
Density | 1.28 |
Melting Point | 240-241 °C (dec.)(lit.) |
Flash Point | 3℃ |
Water Solubility | 260 g/L (20 ºC) |
Appearance | Morphological Crystals or Crystalline Powder, color White |
pKa | pK1:9.83(+1) (25°C) |
PH | 5.5 (260g/l, H2O, 20℃) |
Storage Condition | Inert atmosphere,Room Temperature |
Stability | Stable. Incompatible with strong oxidizing agents. |
Physical and Chemical Properties | Chemical quality is a white solid, m.p.235 ℃ (decomposition), soluble in water, insoluble in organic solvents, easy to absorb moisture. |
Use | Uses S-methyl isothiourea sulfate is an intermediate for the preparation of guanidine, which can be used to prepare fungicides diimuron, ethvery, insecticides pyrimidophanate, anti-aphidb, etc. Used as intermediate of medicine and pesticide |
Hazard Symbols | Xn - Harmful |
Risk Codes | 22 - Harmful if swallowed |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
RTECS | UM9200000 |
TSCA | Yes |
HS Code | 29309070 |
biological activity
(S)-Methylisothiourea sulfate are inhibitors of iNOS.
Target
Target Value
iNOS
Production method
the preparation method is to add a little water into the reactor, partially dissolve thiourea under stirring, stir for 10min under cooling in a cold water bath, then add resteamed dimethyl sulfate, quickly install two spherical condenser tubes to prevent sudden boiling, remove the cold water bath, spontaneously release heat after the reaction, suddenly boil after 5min, at this time the solid has been mostly dissolved, after the reflux is weakened and balanced, heat is heated and refluxed for 1h, let stand overnight, the reactants solidify, add 95% ethanol and stir for a while, cool with ice water for 0.5h, filter, and wash with 25% ethanol to obtain the finished product.
Solubility | H2O: 0.1 g/mL, clear, colorless |
Sensitivity | Hygroscopic |
BRN | 3917217 |
EPA chemical information | Carbamimidothioic acid, methyl ester, sulfate (2:1) (867-44-7) |